AccelLAB is pleased to announce that it will be featured in Elsevier’s First Edition of the Encyclopedia of Biomedical Engineering. Edited by Prof. Roger Y. Narayan (Dept. of Biomedical Engineering; University of North Carolina), this large multidisciplinary collection aims to become a helpful guide for biomaterial scientists, biomedical engineers, governmental and industrial researchers, and medical practitioners in their research activities. Leading scholars from around the world have contributed with the most recent concepts in the fields of biomaterials, bioengineering, medical devices, regenerative medicine, biomechanics, modeling, medical imaging, instrumentation and biocompatibility evaluation. This important reference work of over 200 chapters and 2080 pages is expected to be published this September. Apart from biomedical engineering applications, this significant book will cover advances in cardiology, drug delivery, gene therapy, orthopedics, ophthalmology, sensing and tissue engineering.
Very honored to have received this invitation to contribute, our colleagues Dr. Michel Assad and Dr. Nicolette Jackson have reviewed the latest biocompatibility and preclinical animal models for orthopedic research in a unique book chapter, entitled: “Biocompatibility evaluation of orthopedic biomaterials and medical devices: a review of safety and efficacy models”. Already available on-line on Elsevier’s Biomedical Science Reference Module, this chapter will present the state-of-the-art animal models and will specifically appear in the Encyclopedia’s Medical Device Section, edited by renowned biomaterials expert, Prof. Diego Mantovani (Director, Lab for Biomaterials and Bioengineering; Laval University). This review summarizes the biocompatibility framework to demonstrate an appropriate biological response, as well as orthopedic implant innocuity, efficacy, functionality and performance. The most recent advances in preclinical models are presented for study designs that simulate the clinical setting in the field of orthopedics. Histology, histomorphometry, and histopathology analyses, as well as imaging modalities and mechanical testing, are also described in order to evaluate orthopedic biomaterials for their safety and performance.